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New UC study finds heavy cannabis use affects human genome

University of Canterbury 6 May 2020
Family First Comment: New Zealand 🇳🇿 based research…

“there is already strong evidence that chronic, heavy use of cannabis can increase the risk of mental health issues such as depression and schizophrenia. It is also associated with heart disease. This study shows how cannabis use is linked to changes in gene pathways that may explain the link between heavy cannabis use and those adverse health outcomes.”

Heavy cannabis use has an impact on human DNA but the effect is stronger in people who smoke tobacco as well, according to new University of Canterbury (UC) research.

The study, recently published in Translational Psychiatry, investigates how heavy cannabis use can lead to alterations in “DNA methylation” – chemical changes in the body that influence how our genes work.

UC College of Science lecturer Dr Amy Osborne, lead author of the UC study, in collaboration with colleagues from the University of Otago Christchurch, University of Otago, and ESR, says there is already strong evidence that chronic, heavy use of cannabis can increase the risk of mental health issues such as depression and schizophrenia. It is also associated with heart disease.

“This study shows how cannabis use is linked to changes in gene pathways that may explain the link between heavy cannabis use and those adverse health outcomes,” she says. “However, in terms of the effect on the genome and DNA methylation, cannabis appears to have a distinct and somewhat more subtle effect than tobacco. It’s not altering gene pathways to the same extent, but it does affect them in very specific ways.”

The 48 subjects in the new research – all heavy cannabis users – were members of the Christchurch Health and Development longitudinal study. Blood samples were taken when they were aged 28 and analysed for DNA methylation differences between cannabis users and non-users.

The biggest changes were in those who smoked tobacco as well as cannabis, but there was also evidence of distinct and specific DNA alterations in those who smoked only cannabis, compared to non-users.

The most affected genes were identified as those involved in brain and heart function.
READ MORE: https://www.canterbury.ac.nz/news/2020/new-uc-study-finds-heavy-cannabis-use-affects-human-genome.html
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Better to decriminalise cannabis rather than legalise it – bill opponents

Stuff.co.nz – Lynne Bower and Deborah Stevens 6 May 2020
Family First Comment: Boom! Superb commentary – which asks the right questions:
“Setting aside the obvious question of why are we legalising and making readily available a product that is associated with a number of “harms to individuals, families/whānau and communities”, we need to carefully consider whether legalisation will enable any of the bold claims that are made in regards to promoting the wellbeing of New Zealanders. Firstly, legalisation is not necessary for “raising awareness of the health risks associated with cannabis use” — we can do this without legalisation. Further, there is nothing in the bill that says how “access to health and social services, and other kinds of support for families/whānau” will be improved. Further still, we need only look to other jurisdictions that have legalised cannabis for recreational use to see that eliminating the illegal supply of cannabis, restricting young people’s access to cannabis, and making sure the response to any breach of the law is fair, are unlikely to happen.
#saynopetodope

Setting aside the obvious question of why are we legalising and making readily available a product that is associated with a number of “harms to individuals, families/whānau and communities”, we need to carefully consider whether legalisation will enable any of the bold claims that are made in regards to promoting the wellbeing of New Zealanders.

Firstly, legalisation is not necessary for “raising awareness of the health risks associated with cannabis use” — we can do this without legalisation.

Further, there is nothing in the bill that says how “access to health and social services, and other kinds of support for families/whānau” will be improved.

Further still, we need only look to other jurisdictions that have legalised cannabis for recreational use to see that eliminating the illegal supply of cannabis, restricting young people’s access to cannabis, and making sure the response to any breach of the law is fair, are unlikely to happen.

Evidence does not support the argument that the black market and its associated gang involvement will disappear with the legalisation of cannabis. In Canada and California, government-authorised sellers are unable to keep up with the newly created cannabis demand, and government prices are higher than those of the black market. The range of cannabis products available is also greater on the black market. Hence, the black market continues to find support and thrives.

Although the bill sets the legal age of cannabis use at 20 years, this will not guarantee the safety of younger people. Research has found a significant increase in adolescent cannabis-associated emergency department and urgent care visits following legalisation, with greater numbers of young people requiring treatment for acute medical or psychiatric symptoms following cannabis use.

Research from jurisdictions in the USA that have legalised recreational cannabis use also shows that responses to breaches of the law in regard to cannabis are not applied fairly. Minority groups and indigenous people remain disproportionately represented in cannabis-related arrests, contrary to what legalisation proponents suggest.

Alcohol and tobacco companies have invested heavily in the newly created cannabis industry overseas. Cannabis is set to be the next addiction-for-profit industry. Given the way in which corporations are already organising themselves for legal recreational cannabis use, we need to ask ourselves: “Who will really benefit from such legalisation?”

If we recognise that there are harms associated with cannabis — as we do — then legalisation is not the way to address those harms.  A better way forward may be to take the time to explore and publicly discuss the decriminalisation of cannabis, as opposed to its legalisation.

Decriminalisation would facilitate the separation of cannabis use from issues of social justice and health, and provide space in which the work of focusing on the wellbeing of New Zealanders can be better addressed. It will be wiser to vote “no” to the proposed Cannabis Legalisation and Control Bill, and instead push for public discussion on the decriminalisation of cannabis.

— Dr Lynne Bowyer and Dr Deborah Stevens are co-directors of The New Zealand Centre for Science and Citizenship Trust.
READ MORE: https://www.stuff.co.nz/national/health/300005217/better-to-decriminalise-cannabis-rather-than-legalise-it–bill-opponents

 

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How many joints can be produced from home

The proposed law if NZ votes to legalise recreational cannabis use says:

ANY PERSON WILL BE ALLOWED TO GROW TWO PLANTS FOR PERSONAL USE, TO A LIMIT OF FOUR PER HOUSEHOLD

So how many joints could be produced from home?

ANSWER:
Obviously these numbers are very general because grow techniques vary, but conservatively one marijuana plant in a hydroponic indoor set-up could produce a harvest about every 110 days and from that harvest the grower would get between 198 grams and 311 grams of buds (Median 254.5grams) and also about 198 grams to 311 grams of leaf (Median 254.5grams).  In NZ the buds are desired for smoking because they have the highest amount of THC and the leaf is also smoked.  However now in the U.S with legal states whether medicinal or recreational Leaf is now most commonly used by individuals to make concentrated THC by way of Butane Hash Oil (extremely high potency THC), which is also on a side note causing a lot of explosions and fires in the U.S.

Therefore annually one plant could be producing a median of 1,527 grams smokable product per annum.

We estimate that the mean weight of marijuana in a joint is 0.32 g (95% Bayesian posterior interval: 0.30–0.35).

So even if you were generous and said that .5 grams per joint then essentially one plant would yield as a Median 3,054 smoking joints per annum equivalent to 8.36 joints per day.

 NZ legislation is proposing up to 4 plants can be home-grown

4 plants the median would be 12,216 smoking joints per year – equivalent to 33.46 joints per day over the year of the psychoactive substance THC.

And they call it “control”. Go figure!

Melbourne man in drug-induced psychotic state smothers, fatally strangles girlfriend

TVNZ One News 4 May 2020
Family First Comment: “Shea Sturt attacked his girlfriend with scissors and smothered her with a pillow before strangling the brain surgery survivor with tracksuit pants to make sure she was dead. He had a long history of violence towards his girlfriend before killing her amid a CANNABIS-INDUCED psychotic state, the Supreme Court of Victoria was told.”

But hey – dope just makes you sleepy eh.
#saynopetodope

Shea Sturt attacked his girlfriend with scissors and smothered her with a pillow before strangling the brain surgery survivor with tracksuit pants to make sure she was dead.

The 33-year-old was in a drug-induced psychotic state when he killed 31-year-old Caitlin O’Brien at their Melbourne home in June 2019.

About a month before she died, the nurse had a brain tumour removed.

But Ms O’Brien lived in fear of her violent and increasingly erratic boyfriend.

She called police two days before the murder, when Sturt began having delusions he was Jesus.

He also forced Ms O’Brien to eat an apple so she could be like Eve and be enlightened.

Sturt was taken to hospital but released that night.
READ MORE: https://www.tvnz.co.nz/one-news/world/melbourne-man-in-drug-induced-psychotic-state-smothers-fatally-strangles-girlfriend

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How much legal cannabis could raise in tax revenue – and why it might fail

NewsHub 1 May 2020
Family First Comment: So how good has alcohol and tobacco done at covering the significant health and societal costs? Terrible!!! It’s been a fiscal disaster.
The article also says…
“….but only if it’s good enough to wipe out the black market.”
As we already know, no place that has legalised has achieved that. Just 29% of Canadian cannabis users buy all of their product from a legal source. California’s projected marijuana tax revenue by July 2019 is nearly half of what was originally expected when the state began retail sales in 2018, since most consumers continue to purchase marijuana from the black market in order to avoid high taxes.
Just another smokescreen from the Drug Foundation’s friends.
Read more: https://saynopetodope.org.nz/black-market-continues/  https://saynopetodope.org.nz/social-costs-v-tax/

A new report shows a legalised cannabis market could raise $490 million in taxes each year – but only if it’s good enough to wipe out the black market.

And with the Government hoping to design it in a way that discourages use over time, the New Zealand Institute of Economic Research (NZIER) fears it might not be.

It’s released a new report into how the proposed legal cannabis system proposed by the Government might work. The findings are based on a similar report the group did a few years ago, but updated with new evidence collected from places where it’s been legalised recently, such as Canada and parts of the United States.

“The evidence from America is you can wipe out the black market if you have an open, regulated regime that allows customers to get access to the product they want and allows low-cost production,” principal economist Peter Wilson told Newshub.

“But the Government seems to be saying it doesn’t want that to happen – it doesn’t want a commercial market. It wants to see use reduced through time.”

The Government’s proposed scheme would see cannabis tightly restricted, with limits on potency and amounts any individual can possess at any one time. It would also be taxed – NZIER saying this could bring in $490 million.

“That is dependent on the legal market taking over from the illegal market, and we think the Government’s got to do a bit more work to do to make sure that happens. We hope there will be some more consultation and discussion before the legislation is passed.”

The fear is if the legal regime is too expensive or difficult to access, users will simply keep turn back to the black market.
READ MORE: https://www.newshub.co.nz/home/politics/2020/05/how-much-legal-cannabis-could-raise-in-tax-revenue-and-why-it-might-fail.html

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Cannabis referendum: Drug Foundation calls for lower THC limit under proposed cannabis regime

NewsHub 3 May 2020 
The NZ Drug Foundation has flagged some concern about the suggested THC limit for recreational cannabis under the proposed legal framework.

The Government has released the final legislation on which New Zealanders will vote in this year’s planned referendum.

Under the proposed regime, authorities could restrict dried cannabis to contain no more than 15 percent THC – the main psychoactive ingredient.

The foundation’s director Ross Bell said that seems too much.

“The work that I’ve seen done by ESR shows that generally New Zealand cannabis on the black market is about 6 to 8 percent, which I think is a more reasonable number.”

Bell said the Government may want to consider dropping that potency limit.
READ MORE: https://www.newshub.co.nz/home/politics/2020/05/cannabis-referendum-drug-foundation-calls-for-lower-thc-limit-under-proposed-cannabis-regime.html

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Making hash cookies at home could soon be allowed as finalised recreational cannabis legislation revealed

NewsHub 1 May 2020
You could soon be able to produce cannabis-infused products without a license at home as long as you do not use dangerous methods, if Kiwis vote to pass the recreational cannabis legislation.

But it is important to remember that even if Kiwis vote to pass the legislation, that does not mean it will become law. After the election, the incoming Government can introduce a Bill to Parliament that would legalise it.

A ban will be put in place on importing cannabis – only licensed businesses will be able to import the seeds. The Government also aims to separate business that can grow cannabis and produce products from those that sell it.

At the same time, the Government wants to reduce people’s dependency on cannabis by investing in addiction services, with a focus on lowering the use amongst young people by increasing the age of first use.
READ MORE: https://www.newshub.co.nz/home/politics/2020/05/making-hash-cookies-at-home-could-soon-be-allowed-as-finalised-recreational-cannabis-legislation-revealed.html

Govt reveals final cannabis legislation to be voted on in referendum
TVNZ One News 1 May 2020
Even if New Zealanders vote to legalise cannabis in this year’s planned referendum, they will not be allowed to purchase edible products right away.

The final legislation – to be considered by the public – has been published this morning and outlines a phased approach to making the drug legal.
READ MORE: https://www.tvnz.co.nz/one-news/new-zealand/govt-reveals-final-cannabis-legislation-voted-in-referendum

Govt reveals final cannabis legislation to be voted on in referendum
Radio NZ News 1 May 2020
The final legislation – to be considered by the public – has been published this morning and outlines a phased approach to making the drug legal.

Only fresh and dried cannabis, including plants and seeds, would be immediately approved for production and sale under the new regime.
READ MORE: https://www.rnz.co.nz/news/political/415566/govt-reveals-final-cannabis-legislation-to-be-voted-on-in-referendum

Reeferendum: Proposed big fines for cannabis corporates, ‘help not handcuffs’ for young cannabis users
NZ Herald 1 May 2020
A national cap on the amount of cannabis that can be grown and heavy fines, including jail time, for unlawful sale or supply are key features of the proposed framework for legalising cannabis for personal use.

But fines for underage (younger than 20) possession are comparatively light, and could even be waived if the young offender agreed to a drug treatment or education programme.

“We don’t want to criminalise a younger offender, but we do want to criminalise those seeking to exploit or take advantage of young people,” Justice Minister Andrew Little told the Herald.
READ MORE: https://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=12328798

Government reveals cannabis referendum legalisation details
Stuff co.nz 1 May 2020
Proposed cannabis legalisation will ban items designed to appeal to young people, set a four-year prison term for selling to under 20-year-olds and allow cannabis ‘coffee shops’ to open.

On Friday, the Government released details of the Cannabis Legalisation and Control Bill, which will be voted on in one of two referendums at this year’s general election.

It was released in draft form in December last year.

REGULATION
Regulating how cannabis is produced and supplied would be done by limiting the total amount of licensed cannabis for sale, controlling the potency and contents of licensed cannabis and cannabis products and applying an excise tax when a product is packaged and labelled for sale.

The tax would be based on weight and potency and a levy, similar to that applied to alcohol and gambling, would fund services to reduce cannabis harm.

There would be restrictions on the appearance of premises that would include rules against promoting the fact that cannabis is available for purchase inside.

A licensing system would also be set up for all cannabis-related businesses.

It would also regulate location and trading hours for premises where cannabis is sold or consumed, in consultation with local communities.

It bans people from importing cannabis and allows only licensed businesses to import cannabis seeds.

An assessment would apply to all licence applicants, directors, and people overseeing cannabis operations under an authorisation and police vetting would be included in the process.

Some less serious previous convictions will not, on their own, disqualify the person.

A cap would limit the amount of cannabis available for sale in the licensed market and no licence holder would be able to hold more than 20 per cent of the cap.

A cabinet paper reveals the bill did not address certain policy issues that have been deferred until after the referendum.

This included current laws under the Misuse of Drug Act and the interface with medical cannabis.

The Cabinet paper also states the law would face international legal issues and have foreign policy implications because New Zealand was currently bound by the United Nations Drug Conventions.

The law would be reviewed after five years of operating as a licensed regime.
READ MORE: https://www.stuff.co.nz/national/politics/121373149/government-reveals-cannabis-referendum-legalisation-details

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Cannabis Legalisation – ‘THIS IS NOT THE MAGICAL CURE’

Cannabis referendum: All you need to know about what your vote means
NZ Herald 25 April 2020
Family First Comment: “Seeing whānau members who can’t go without cannabis every day for 40-50 years. Seeing 15 year-olds who just want to use cannabis every day. It is insidious, it is damaging, and it is powerful in our communities. This is not the magical cure people often portray it as. Because the underlying reasons for that treatment of Māori, that institutional bias in criminal justice, remains. With the justice system, with the health system – we need to fix those first. Otherwise we just get all the downsides and none of the positive fixes.”

What are the arguments against it?
The main concern from opponents is that legalisation will make cannabis even more accepted and available in this country, and that could lead to an increase in consumption and cannabis-related harm.
The Royal Society of New Zealand reviewed the science on cannabis’ risks and benefits last year, and found there were some negative outcomes from cannabis use (but also big gaps in data and research).
In particular, recreational cannabis was associated with mental illness, especially among youth, drug use disorders, respiratory illness, impaired cognition and increased road accidents.

“People may assume cannabis is largely safe as it has been used by people for so long, but this is not necessarily the case,” said Professor Michelle Glass, Head of the Department of Pharmacology and Toxicology at University of Otago.

Opponents of legal cannabis say the North American experience showed it was not the utopia many believed it would be.

In the first US state to legalise, Colorado, more people were being admitted to hospital for cannabis-related problems, and there were more reports of mental health cases linked to marijuana. At the same time, youth consumption had fallen. It also fell in Canada after legalisation 18 months ago, while use had risen among adults in their 60s.

In California and Canada, legalisation had failed to stamp out the black market, partly because of high taxes and bureaucracy which had stifled legal businesses.

Some opponents are sceptical about the touted benefits of legalisation for Māori. Changing the legal status of one drug will do little to shift the entrenched biases in the justice and health systems, they say. In the US, racial divides, including disproportionate arrests of African-Americans for drug possession, have persisted after legalisation.

And despite a promise to keep the cannabis industry small and local, New Zealand had a poor record in caving to big alcohol, tobacco and gambling interests. “I have little confidence in our government being able to handle it,” said Peter Adams, a public health researcher at the University of Auckland.

How does it compare to other countries?
New Zealand would be the fifth country to legalise cannabis, after Uruguay, Georgia, Canada and South Africa. Several US states have also legalised and the state of Australian Capital Territory (ACT) legalised recreational cannabis in January.

‘THIS IS NOT THE MAGICAL CURE’
In his work as a minister, Reverend Hirini Kaa has witnessed the more sinister side of cannabis use.

“Seeing whānau members who can’t go without cannabis every day for 40-50 years,” he said.

“Seeing 15 year-olds who just want to use cannabis every day. It is insidious, it is damaging, and it is powerful in our communities”, he said.

Dr Kaa, who is also a historian and kaiārahi (Māori and Pacific advisor at the University of Auckland, said he supported the increasingly health-based approach to illicit drug use in New Zealand and the shift away from punitive drug laws which disproportionately hurt Māori.

But he will vote “no” to legalising recreational cannabis use in this country, he said.

“This is not the magical cure people often portray it as. Because the underlying reasons for that treatment of Māori, that institutional bias in criminal justice, remains.

“With the justice system, with the health system – we need to fix those first. Otherwise we just get all the downsides and none of the positive fixes.”

He cited the example of the United States, where legalisation in some states had not changed the fortunes of African-Americans or indigenous people. They were still far more likely to be arrested and convicted of drug possession offences, and had not been at the heart of the “Green Rush”.

Dr Kaa said he believed he was in the minority In his iwi, most of whom backed reform. Cannabis had “found its way into our culture” through Bob Marley and reggae, he said. It played a role in its illegal economy. And if it were legalised, Māori stood to benefit from the economic opportunities it created in hard-up regions like the East Cape and the Far North.

But when it came to big social policy changes, New Zealand did not look back, he said.

“We don’t question the impact. Look at the alcohol laws. Anyone look back and see the impact on Māori? No. We do this, clap ourselves on the back for being progressive, and then Māori will have to clean up the mess in our communities.

“I hope people who are going to treat this as some kind of great, progressive leap forward understand the impact that it’s actually going to have in certain communities that New Zealand doesn’t even want to hear from, and doesn’t look back on.”
READ MORE: https://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=12327184 (behind paywall)

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A mom shares her concerns about 4/20 and cannabis culture

I’m a mom. I’m sick of this in-your-face cannabis culture
Los Angeles Times 17 April 2020
Family First Comment: “once your kid has a problem with drugs, the ubiquity of pots shops and how cool they look and their pervasive promotion across the city can feel disturbing. It’s as if the schools and public health professionals and parents are giving kids one message and the billboards that litter the city are giving them another. Which seems cooler to a 16-year-old? Earnest mom talks or rainbow billboards? When I was a kid, I know which one I would have chosen.”
#saynopetodope
VoteNO.nz

Our daughter got into college on the East Coast and packed up her winter clothes and some hard-won life lessons and is thriving now. But her story could easily have gone in a different direction. I don’t know if pot is a “gateway drug,” but you don’t have to watch the film “Beautiful Boy” biting back tears to know that from a little problem can grow life-changing trouble before you, the parent, even know the seed has been planted.

A few months ago, our 16-year-old was found with a vape pen. I was furious. I was so furious I stayed quiet the entire 30-minute ride home from his high school. He sat next to me in the passenger seat. “Mom, I’m sorry,” he said. “It was a stupid thing to do.” I looked at him and said, “I don’t want to say anything I will regret, so I am not going to talk right now.” I had a pit in my stomach thinking, “Not this again.”

As we got into our neighborhood, we drove by a billboard that featured a woman with pink and yellow rainbow hair and silver eyebrows, with a large, bubble-lettered sign that read “Kushy Punch.”

If I was 16 and everybody was vaping strawberry nicotine or Red Sundae cannabis or whatever Kushy Punch is, I’m sure I’d want to do it too. I grew up in the 1980s and we smoked pot in high school. I got it mostly from friends and my parents didn’t pay much attention — it was the ’80s. But the marijuana wasn’t particularly potent. We didn’t smoke it through USB ports. It wasn’t promoted on every corner or by every social media influencer (we didn’t have social media or influencers back then). It was a simpler time. But maybe every generation thinks that.

I didn’t want to ruin Amy’s cannabis shopping spree. And I don’t think dispensaries are the root of the teen weed issue. But once your kid has a problem with drugs, the ubiquity of pots shops and how cool they look and their pervasive promotion across the city can feel disturbing. It’s as if the schools and public health professionals and parents are giving kids one message and the billboards that litter the city are giving them another. Which seems cooler to a 16-year-old? Earnest mom talks or rainbow billboards? When I was a kid, I know which one I would have chosen.
READ MORE: https://www.latimes.com/lifestyle/story/2020-04-17/4-20-marijuana-cannabis-culture

Colorado mum Jo worked in youth drug prevention educating young people about the risk behaviours, and also worked in drug testing.
Jo has a warning for New Zealand parents based on her own harrowing experience of marijuana within her family, and also the effect of legalisation of recreational marijuana in her home state of Colorado.
Read more: www.saynopetodope.nz

Legalising cannabis would result in more people suffering psychosis

Daily Mail 12 April 2020
Family First Comment: Even the experts are changing their minds after seeing the evidence..
“Previously the expert – a professor at the Institute of Psychiatry at King’s College London – had supported tightly controlled legalisation married with public education campaigns spelling out the risks, but growing evidence about the harm cannabis causes had made him change his mind about legalising the Class B drug. He said the experience of places that had decriminalised or legalised it – from Portugal and the Netherlands to swathes of North America – had made him think again.”
#saynopetodope

 Legalising cannabis would result in soaring numbers of people suffering from schizophrenia-like psychosis, one of Britain’s top psychiatrists has warned.

Evidence now shows that when the drug is legalised, greater numbers smoke it more frequently and in stronger varieties.

These factors increase the incidence of cannabis-related psychosis, according to Professor Sir Robin Murray, an authority on the risks of the drug to mental health.

He predicted that ‘big cannabis’ firms with scant regard for people’s health will ‘seduce’ the Government into reforming the law – and the State will then find itself in thrall to the new industry because of the tax and jobs it provides.

The warning is a major intervention from Professor Murray, who told The Mail on Sunday growing evidence about the harm cannabis causes had made him change his mind about legalising the Class B drug.

Previously the expert – a professor at the Institute of Psychiatry at King’s College London – had supported tightly controlled legalisation married with public education campaigns spelling out the risks.
READ MORE: https://www.dailymail.co.uk/news/article-8211293/Legalising-cannabis-result-people-suffering-psychosis.html

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